Mussel-inspired polydopamine coating as a universal route to hydroxyapatite crystallization. A mussel-inspired persistent ROS-scavenging, electroactive, and osteoinductive scaffold based on electrochemical-driven in situ nanoassembly. 3D printing of lotus root-like biomimetic materials for cell delivery and tissue regeneration. Hierarchical intrafibrillar nanocarbonated apatite assembly improves the nanomechanics and cytocompatibility of mineralized collagen. Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up. Gautieri, A., Vesentini, S., Redaelli, A. A proposed mechanism for material-induced heterotopic ossification. Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation. Hierarchical structures of bone and bioinspired bone tissue engineering. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Bone tissue engineering: from bench to bedside. A detailed history of calcium orthophosphates from 1770s till 1950. Self-healing fibre reinforced composites via a bioinspired vasculature. In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Tissue-engineered autologous grafts for facial bone reconstruction. These researchers studied the bone-forming mechanism of biodegradable magnesium alloy implants and conducted a clinical study that confirmed total implant degradation and bone-defect regeneration within 1 year.īhumiratana, S. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Size matters: defining critical in bone defect size! J. Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects. Injectable osteogenic microtissues containing mesenchymal stromal cells conformally fill and repair critical-size defects. Finally, we discuss unmet needs and current challenges in the development of ideal materials for bone-tissue regeneration and highlight emerging strategies in the field.Īnnamalai, R. We outline the materials-design pathway from implementation strategy through selection of materials and fabrication methods to evaluation. In this Review, we provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans. Scalable fabrication technologies that enable control over construct architecture at multiple length scales, including three-dimensional printing and electric-field-assisted techniques, can then be employed to process these biomaterials into suitable forms for bone-tissue engineering. Successful materials design for bone-tissue engineering requires an understanding of the composition and structure of native bone tissue, as well as appropriate selection of biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals and composites.
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